translationell barncancerforskning med särskilt fokus på resistens mot cytostatika-behandling och immunoterapier.
Maria Lindqvist,PhD
Kontakta oss
Adress:
translationell barncancerforskning
Kungsholmen, 11240 Stockholm
E-post:
maria.lindqvist@educateandhelplocally.eu
Designed by me Maria Lindqvist,PhD
A quest towards curing childhood cancer as well as pinpointing better molecular biomarkers
Varje år får ungefär 300 barn cancer i Sverige. Vissa får cancer på grund av ärftliga faktorer andra får förmodligen på grund av miljö påverkan. Förmodligen får också vissa barn cancer på grund av både ärftliga samt miljöfaktorer, en bättre förståelse angående cancerns uppkomst kan hjälpa oss att kunna finna/utveckla så kallade skräddarsydda läkemedel för varje individ som drabbas av cancer. Biomarkörer hjälper oss att identifiera de olika cancer formerna i så tidig skede som möjligt samt så rätt som möjligt.
Kontaktuppgifter: forskning@barncancerfonden.se
Arrangör: Institutionen för kvinnors och barns hälsa, Karolinska institutetSlutar: 09 May 2017, 12:00 AM
From concept to clinic: a roadmap for DNA methylation biomarkers in liquid biopsies
Setting Standards in the Delivery of Pediatric Cancer Care
Leaders of the Pediatric Cancer Committee discuss new accreditation
Strengthening Childhood Cancer Care: IAEA and St Jude Begin Development of Radiotherapy Curricula
Launch of the revised European Standards of Care for Children and Adolescents with Cancer: Driving change across Europe
Good to know!
It seemed like Duke scientists had developed a "Holy Grail" of cancer treatment. Then the truth came out. In this week's Globe Magazine cover story, reporter Mike Damiano takes readers inside the scandal that ended with broken careers, betrayed patients, and contributed to a lasting legacy of doubt in scientific institutions.
SCIENTISTS FIND A NEW EPIGENETIC SWITCH THAT ACTIVATES GENES IN EMBRYONIC DEVELOPMENT
Cancer immunotherapy: the quest for better biomarkers
Combination immunotherapy for rare cancers shows improved efficacy and survival rates
Shaping immunity: The secrets behind the shape of neutrophils
Microglia in pediatric brain tumors: The missing link to successful immunotherapy
New approach for the treatment of pediatric brain diseases: microglia replacement opens up new therapeutic possibilities
Microglia in radiation-induced brain injury: Cellular and molecular mechanisms and therapeutic potential
Chemotherapy-induced cognitive impairment and glia: A new take on chemobrain?
Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment
How brain fluid flow predicts survival in glioblastoma
Plant-based nutrient improves immune cells' ability to fight cancer
Exploring the role of plant-based diets in cancer prevention and care
How Diet May Boost the Power of Cancer Immunotherapy
Neurofilament light chain levels as an early predictive biomarker of neurotoxicity after CAR T-cell therapy
Biomarkers related to immune checkpoint inhibitors therapy
LRIG1 could serve as important biomarker to distinguish between glioma types and grades
Research on predictive biomarkers related to gut microbiota and its metabolites for the efficacy of immunotherapy has been developing rapidly; nevertheless, heterogeneity across cohorts exists due to the influence of host diets, lifestyle, medication, and geographical distribution. Furthermore, by analyzing the composition of exhaled breath, the novel and non-invasive eNose technology may have a broader application beyond lung cancer
The Brave New World of Circulating DNA as a Diagnostic Tool in Oncology
Unlocking Personalized Immunotherapy: New Immune Biomarkers Identified in Pediatric Germ Cell Tumors
Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma
Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors
Computational prediction models are transforming the way we use clinical biomarkers, a change that is evident not only in current applications but also in ongoing research. These models, by integrating multimodal data related to the immune system and historical knowledge, have established mechanistic models within systems biology aimed at revealing the mechanisms of immunotherapy and identifying key factors for its efficacy
Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges
Based on published studies and future trials, clinical implementation of liquid biopsies in pediatric solid tumors is anticipated for several applications. Firstly, in a potential cancer screening setting for early diagnosis. However, this seems dubious for the general pediatric population and will likely only be relevant for specific risk groups, such as children with genetic predisposition. More relevant is risk-stratification following diagnosis and subsequent guidance of treatment management
The Role of Liquid Biopsy in Neuroblastoma: A Scoping Review
Better monitoring and treatment of childhood cancer with liquid biopsies
Liquid biopsies offer hope for children with neuroblastoma
The European Genome-phenome Archive (EGA) is a global network for permanent archiving and sharing of personally identifiable genetic, phenotypic, and clinical data generated for the purposes of biomedical research projects or in the context of research-focused healthcare systems.
MONALISA: A Privacy-Preserving Infrastructure Supporting Liquid Biopsies to Monitor Relapsed Neuroblastoma
Advancing cancer care: The role of liquid biopsy in tumour profiling
Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions
By focusing on ribonucleotide reductase (RnR)—a pivotal enzyme in DNA synthesis and in cancer growth—these and other aspects of the disease are demystified. For example, this viewpoint reveals the proximate cause of uncontrolled cell growth: the hyperactivity of RnR, as confirmed by studies of retinoblastoma and HPV-related cervical cancers. This perspective also suggests a way to defeat cancer, as the free radical—essential for the activity of RnR—can be quenched by a stream of electrons.
Overall, our results demonstrate that rare germline SVs that span coding and noncoding loci are important risk factors for pediatric solid tumors. We observed stronger SV effects in neuroblastoma relative to Ewing sarcoma, which is consistent with the markedly earlier age of onset in neuroblastoma. We estimate that rare SVs contribute 1.1 to 5.6% of liability for these cancers, which underscores a modest yet meaningful role for rare germline SVs in the missing heritability of pediatric solid tumors. Our work supports the integration of germline SVs into clinical practice and research efforts related to pediatric solid tumor predisposition.
Deepened understanding of the developmental origin of pediatric cancer, which is associated with lineage-specific genetic dependency and also vulnerabilities conferred by germline mutations in cancer predisposition genes
Genen som styr prognosen vid neuroblastom
https://www.vetenskaphalsa.se/genen-som-styr-prognosen-vid-neuroblastom/
Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy
Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from diagnosis to long-term follow-up.
Research identifies factors for long-term myeloma remission
Biomarkers That Predict Heart Disease Risk in Pediatric Cancer Survivors
detection of ALT-TFs in blood and cell-free DNA represents a method for liquid biopsy analysis, with implications for early detection, patient stratification, disease monitoring and treatment selection
Neuroblastoma (A project by Maria Lindqvist,PhD)
Medulloblastoma ( A project by Maria Lindqvist,PhD )
First-ever Cancer Biomarker Awareness Day!
CANCER BIOMARKER AWARENESS DAY: Advanced Biomarker Testing is Hope
Professor Kim Vettenranta har haft en central roll i att utveckla behandlingen av leukemi hos barn i Finland.
Numera tillfrisknar 98 procent av alla barn som insjuknar i leukemi.
https://www.helsinki.fi/sv/nyheter/donationer/leukemi-besegras-med-hjalp-av-forskning
Intravenöst C-vitamin kan förbättra livskvaliteten hos cancerpatienter
https://www.vitaminkliniken.se/blog/2024-05-06/intravenos-vitamin-c-i-varden-av-cancerpatienter/index.html
En tredjedel av barn med leukemi har D-vitaminbrist
https://www.onkologiisverige.se/en-tredjedel-av-barn-med-leukemi-har-d-vitaminbrist/
forskningen om vitamin D3 och cancer är fortfarande i sin linda, men de bevis som hittills finns tyder på att det har potential att bli en värdefull allierad i cancerbehandling. En balanserad kost som säkerställer ett tillräckligt intag av D-vitamin , tillsammans med regelbunden, måttlig exponering för solen och en hälsosam livsstil, är åtgärder som alla kan vidta för att förbättra sina chanser att hålla sig friska och potentiellt bidra till effektiviteten av cancerbehandlingar.
https://www.frequenz-therapie.com/swe/blog/vitamin-d3-en-potentiell-sammansaettning-i-cancerterapi
Decoding mitochondria's role in immunity and cancer therapy
https://www.sciencedirect.com/science/article/pii/S0304419X24000386
Överaktiva mitokondrier vid aggressiv hudcancer kan blockeras med befintliga läkemedel
MRT is a less well known form of cancer treatment, but can be highly effective, even when the cancer has spread widely. Its uses are growing, and there are increasing numbers of clinical trials of MRT in a variety of types of childhood cancer.
https://www.cclg.org.uk/magazine-articles/molecular-radiotherapy-childrens-cancers
Physicians usually recommend proton radiation therapy to treat solid tumors in children because it sends less radiation to healthy tissue than standard radiation therapy does.
Less radiation means fewer short- and long-term side effects and lower risk for serious problems that may result from treatment. Studies show that proton therapy may help protect children from development problems, growth delays, lower IQ, cancer forming in other parts of their body and other health problems, compared to standard X-ray radiation.
The Effect of Music Therapy as an Adjunctive Treatment in Pediatric Cancer Patients Receiving Traditional Therapies: A Systematic Review
https://pmc.ncbi.nlm.nih.gov/articles/PMC11409770/
VIDEOS HELP KIDS WITH CANCER SKIP ANESTHESIA DURING RADIATION
https://www.futurity.org/kids-with-cancer-anesthetia-radiation-2917312/
The data show that exercise works: it shortens hospitalizations 17%
https://www.mapfre.com/en/insights/innovation/physical-exercise-helps-cure-children-with-cancer/
Researchers identify new therapeutic approach to tackle radiation resistance in childhood brain tumourshttps://www.utoronto.ca/news/researchers-identify-new-therapeutic-approach-tackle-radiation-resistance-childhood-brain?utm_source=miragenews&utm_medium=miragenews&utm_campaign=news
FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy
Let's Talk About Pediatric Brain Tumor Biomarkers
https://braintumor.org/news/lets-talk-about-pediatric-brain-tumor-biomarkers/
Biomarker Testing Opened the Door to Targeted Treatment for a Toddler with Brain Cancer
Biomarkers linked to side effects from cancer immunotherapy
https://www.utsouthwestern.edu/newsroom/articles/year-2025/sept-immunotherapy-biomarkers.html
Study identifies immune biomarkers for personalized therapies in pediatric germ cell tumors
Biomarkers of CAR T-Cell Response in Pediatric Leukemia Found
A Breakthrough in Early Epigenetic Markers for Childhood Leukemia
Universal, essential biomarker identified for childhood neuroblastoma
Largest study on infant-type hemispheric glioma reports factors to guide treatment approaches
Immunotherapy for children with sarcoma
https://www.ccia.org.au/blog/immunotherapy-for-children-with-sarcoma
Next-Generation Treatment for Pediatric Cancer: Advancing Immunotherapy through Combinations
Thanks to immunotherapy, doctors have another option when more traditional ALL drugs stop working. Now, they can train patients' own immune cells to find and destroy their cancer.
Unlike some immunotherapy approaches such as CAR T-cell therapy, which use a patient's own cells, γδT cells can be taken from healthy donors and safely given to patients without causing a harmful immune reaction. This 'off-the-shelf' treatment offers a promising new option that could be delivered quickly and more cost-effectively to those who need it most.
Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1550652/full
Cancer Immunotherapy! keep going strong!
https://pediatricsnationwide.org/2025/03/10/breaking-new-ground-in-cancer-immunotherapy/
The Next Generation Immunotherapies: From Innovative Approaches to Overcoming Resistance and Beyond is the European Association for Cancer Research's (EACR) inaugural virtual conference on this topic, scheduled for February 24–25, 2026.
https://oncodaily.com/event/next-generation-immunotherapies-406112
Hypertension drugs could improve cancer immunotherapy efficacy
Why brain cancer is often resistant to immunotherapy
Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.
https://www.broadinstitute.org/news/why-brain-cancer-often-resistant-immunotherapy
Overview of toxicities associated with immune checkpoint inhibitors
Halifax doctor sees game-changing results for cancer treatment with targeted hyperthermia therapy
Emerging hyperthermia applications for pediatric oncology
https://www.sciencedirect.com/science/article/abs/pii/S0169409X20301617
Exposure to combination of pesticides increases childhood cancer risk
Exposure to a 10% mixture increased brain cancer rates by 36%, leukemia rates by 23% and overall pediatric cancer rates by 30% in Nebraska...
https://www.theguardian.com/us-news/2025/mar/05/pesticides-childhood-cancer-study
Proximity to fracking sites associated with risk of childhood cancer
https://news.yale.edu/2022/08/17/proximity-fracking-sites-associated-risk-childhood-cancer
Radon-Induced Child Cancer Widespread Across US, Even at Low Levels
https://www.newsweek.com/radon-induced-child-cancer-widespread-across-us-1962057
Study shows higher risk of childhood leukemia tied to PFAS exposure from household dust
Study links PFAS in drinking water to increased risk of childhood cancers
The role of immune checkpoints in modulating cancer stem cells anti-tumor immune responses: implications and perspectives in cancer therapy
The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition
Tumor Immune Ecotypes Predict Checkpoint Therapy Success
data suggest that IO biomarkers should be used in patient selection for ICIs
A recent study has identified a significant connection between the loss of TRIM25, a protein involved in immune regulation, and enhanced cancer immunotherapy outcomes through the immune checkpoint
NCI's Childhood Cancer Data Initiative (CCDI) is building a community centered around childhood cancer care and research data. Through better data sharing, we can advance our understanding of cancer biology and improve childhood cancer diagnosis, treatment, quality of life, and survivorship.
UF biostatistician at the forefront of groundbreaking childhood leukemia drug trial
Pediatric Biostatistics Core
The Pediatric Biostatistics Core (RRID: SCR_025834) was established in 2009 with a mission to support pediatric researchers at Emory University and Children's Healthcare of Atlanta, as well as child health researchers at several other Atlanta area institutions including Georgia Institute of Technology and Morehouse School of Medicine. The high-rigor statistical expertise provided by the core bolsters the quality of pediatric research to promote impactful and reproducible research findings across all child health disciplines.
Statistical Methods in Childhood Cancer Research
The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer
Each year in the U.S. there are an estimated 15,780 children between the ages of birth and 19 years of age who are diagnosed with cancer. Approximately 1 in 285 children in the U.S. will be diagnosed with cancer before their 20th birthday. Globally there are more than 300,000 children diagnosed with cancer each year. Every 3 minutes, somewhere in the world a family hears the devastating words that their child has been diagnosed with cancer.
A Critical Review of Statistical Methods for Twin Studies Relating Exposure to Early Life Health Conditions
Analysis of twin data in health sciences
Twin Studies: A Unique Epidemiological Tool
Diskussion/Debatt ALL CANCER TYPES
Rapport visar stora brister i palliativ vård: "Kan förkorta livet"Ett lotteri, där bostadsadressen avgör.
The Chilean Ministry of Health has introduced biomarker-based diagnostics as a core component of its Digestive Cancer Prevention Strategy, a national initiative to reduce gastric and colorectal cancer mortality through early detection.
Knowledge Gaps and Future Directions
There is evidence of the influence of the intestinal microbiota on the response to immunotherapy in cancer. In addition, we lack markers of response to treatment and toxicity, which obliges us to continue our search for them.
Symptom burden, healthcare utilization, and risky behaviors in survivors of the childhood cancer survivor study (CCSS): an observation cohort study
Educational attainment in survivors of childhood cancer in Denmark, Finland, and Sweden
Sharing ideas
Pan's lab work was motivated by an ongoing phase 2 study at St. Jude for pediatric patients with newly diagnosed rhabdomyosarcoma. This trial is a phase 1–2 study, and in the phase 2 part the primary endpoint is event-free survival.
An R package BayesDesign is available at no cost to researchers via R CRAN for convenient use of the proposed methods at
https://cran.rproject.org/web/packages/BayesDesign/index.html
BioArchLinux: community-driven fresh reproducible software repository for life sciences
Why 95% Of Bioinformatics Tools Run On Linux (And What That Means For You)
EN HYLLNING TILL ALLA
LEGENDARISKA GITARRGUDAR
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KOLLA IN VÅRA KONSERTER OCH DIGGA VÅR MUSIK LIVE
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ALBUMET MED ALLA
DINA FAVORITLÅTAR
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SMYGTITT PÅ VÅRT NYA ALBUM
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